20 results

Preclinical Research Shows Senescent Cell Removal Improves Cognitive Function

Preclinical Research Shows Senescent Cell Removal Improves Cognitive Function ... findings indicate that the removal of senescent cells in aging mice improves cognitive ... mice appear in Aging Cell. Senescent cells are those cells in the body that have ... ignored the order to expire. These cells exist in a suspended state. They are ... linger, spewing out toxic chemicals. The cells and their toxic chemicals often are

Mayo Clinic Research News – Zombie Cell Edition

Research News – Zombie Cell Edition ... There are times when a cell must cease its work ... of a normal cell’s limited number of divisions, or when a cell is heading down ... a pathway that leads to cancer. Cells that are stopped from dividing but ... are called senescent cells. These cells, sometimes called zombie cells, are

Toxic Cellular Ooze Linked to Biological Age, Disease and Disability

Cells in the body usually do what they’re ... cues, cells divide, grow, shrink or die as needed. But there are some cells that ... order to expire: senescent cells. Sometimes called "zombie cells" for their undead ... undead lingering, senescent cells have triggered the body’s kill command, but ... Illustration of normal cells (pink) and senescent cells (green). Credit: Donna

Balancing Damage and Protection, Neutrophils May Lead to Cell Aging

Neutrophils May Lead to Cell Aging ... The action of an immune cell called a neutrophil may ... in nearby cells which, over time, may lead to cellular senescence. This new ... new concept may help clarify cell aging. It also suggests targeting neutrophils ... Neutrophils, Senescent Cells The immune system is a collection of cells and proteins

Rocketing Ahead

is a pioneer in researching senescent cellscells that stop dividing and simply ... leads the discovery research work into cell aging for Mayo Clinic’s Center for Biomedical ... the world’s leading authority on senescent cells as a mentor has defined him as ... Deursen, who earned a doctorate in cell biology in the Netherlands, came to ... their suspected link to aging, senescent cells became his focus. Over

Mayo Discovery Finalist for Science Breakthrough

narrowed to five, including the senescent cell research of Mayo’s Jan van Deursen ... his team explored the role of senescent cells in atherosclerosis: “Using mice ... engineered to kill off many of their senescent cells in response to a particular drug ... they found that mice purged of senescent cells carried 60% less plaque than did ... findings that indicated removing scenscent cells from mice would increase their lifespan

Heart Cells Become Zombies, Too, Though they Rarely Divide

Heart Cells Become Zombies, Too, Though they Rarely Divide ... have shown even though heart muscle cells from mice and humans rarely divide ... divide, they can become zombie, or senescent, cells. For patients with heart failure ... avenues of research. Cells that become senescent have, in essence, tripped ... response, cell programming prevents them from dividing, but the cells don’t die

Animal Model Suggests Metabolic Syndrome May Impair Repair

replicator in the mesenchymal stem cell. These act as the raw material for future ... future muscles, cartilage, or bone cells, to name a few. But scientists at Mayo ... that examined how mesenchymal stem cells act in an animal model of metabolic ... and diabetes. They report that stem cells in pigs with metabolic syndrome are ... Stasis for a cell is a state called senescence. These senescent cells hover between